Department of History and Philosophy of Science, University of Cambridge, Free School Lane, Cambridge CB2 3RH, United Kingdom. el260@cam.ac.uk

The story of a fatal hypnotic seance in a castle in provincial Hungary in 1894 was sensationalised by the media and propelled across national and social boundaries within a few days. It stirred public feelings and compelled prestigious medical mandarins, legal professionals and social commentators of the day to express wide-ranging views concerning hypnotic practice. The case intensified social and professional anxieties surrounding hypnosis in late 19th century culture and illustrates the complex relationship between medical hypnotic research, lay hypnosis and widely reported and sensationalised forensic cases.

Neuropsychology, Department of Psychology, University of Freiburg, Engelbergerstrasse 41, D-79085 Freiburg, Germany. halsband@psychologie.uni-freiburg.de

This study examined the fundamental question, whether verbal memory processing in hypnosis and in the waking state is mediated by a common neural system or by distinct cortical areas. Seven right-handed volunteers (25.4 years, sd 3.1) with high-hypnotic susceptibility scores were PET-scanned while encoding/retrieving word associations either in hypnosis or in the waking state. Word-pairs were visually presented and highly imaginable, but not semantically related (e.g. monkey-street). The presentation of pseudo-words served as a reference condition. An emission scan was recorded after each intravenous administration of O-15 water. Encoding under hypnosis was associated with more pronounced bilateral activations in the occipital cortex and the prefrontal areas as compared to learning in the waking state. During memory retrieval of word-pairs which had been previously learned under hypnosis, activations were found in the occipital lobe and the cerebellum. Under both experimental conditions precuneus and prefrontal cortex showed a consistent bilateral activation which was most distinct when the learning had taken place under hypnosis. In order to further analyze the effect of hypnosis on imagery-mediated learning, we administered sets of high-imagery word-pairs and sets of abstract words. In the first experimental condition word-pair associations were presented visually. In the second condition it was found that highly hypnotisable persons recalled significantly more high-imagery words under hypnosis as compared to low-hypnotisables both in the visual and auditory modality. Furthermore, high-imagery words were also better recalled by the highly hypnotisable subjects during the non-hypnotic condition. The memory effect was consistently present under both, immediate and delayed recall conditions. Taken together, the findings advance our understanding of the neural representation that underlies hypnosis and the neuropsychological correlates of hypnotic susceptibility.

Department of Anesthesiology and Pain Clinic, University of Liege, Sart Tilman, Belgium.

The neural mechanisms underlying hypnosis and especially the modulation of pain perception by hypnosis remain obscure. Using PET we first described the distribution of regional cerebral blood flow during the hypnotic state. Hypnosis relied on revivification of pleasant autobiographical memories and was compared to imaging autobiographical material in "normal alertness". The hypnotic state was related to the activation of a widespread set of cortical areas involving occipital, parietal, precentral, premotor, and ventrolateral prefrontal and anterior cingulate cortices. This pattern of activation shares some similarities with mental imagery, from which it mainly differs by the relative deactivation of precuneus. Second, we looked at the anti-nociceptive effects of hypnosis. Compared to the resting state, hypnosis reduced pain perception by approximately 50%. The hypnosis-induced reduction of affective and sensory responses to noxious thermal stimulation were modulated by the activity in the midcingulate cortex (area 24a'). Finally, we assessed changes in cerebral functional connectivity related to hypnosis. Compared to normal alertness (i.e., rest and mental imagery), the hypnotic state, significantly enhanced the functional modulation between midcingulate cortex and a large neural network involved in sensory, affective, cognitive and behavioral aspects of nociception. These findings show that not only pharmacological but also psychological strategies for pain control can modulate the cerebral network involved in noxious perception.

To determine from the published evidence whether autogenic training as sole therapy is effective for prevention of tension-type headaches in adults. METHOD: Systematic review of controlled trials. Literature searches were performed in January 2005 in six major databases, specifically Medline, EMBASE, AMED, CENTRAL, PsychInfo and CINAHL and information was extracted and evaluated in a pre-defined manner. RESULTS: Seven controlled clinical trials were included in the review. The methodological quality of these studies was low. Patient samples were generally representative of the more severely affected cases. None of the studies show autogenic training to be convincingly superior to other interventions care. Some trials suggested that the effect of autogenic training is no different from hypnosis and inferior to biofeedback. CONCLUSION: There is no consistent evidence to suggest that autogenic training is superior to other interventions for prevention of tension headaches, or different from other forms of relaxation. Further studies should investigate the use of standard autogenic training in patients with moderate headache.

Senior Lecturer, Faculty of Health Studies, Buckinghamshire Chilterns University College, Chalfont St Giles, Buckinghamshire HP8 4AD, UK. N.Kanji@bcuc.ac.uk

Previous research suggests that mirror-gazing is efficacious for the facilitation of anomalous experiences. The present experiment tested the hypothesis that the incidence of such experiences is a function of the demand characteristics of the procedure. Participants were randomly allocated to one of two conditions and completed a battery of trait and state measures. Individuals who were given suggestions for anomalous experiences, relative to those who were not, reported a greater number of visual, and a suggestively greater number of vocal, hallucinations. The experience of a descriptively dissociative phenomenological state was the strongest predictor of the reporting of anomalous experiences, but only correlated with the experience of anomalous perceptions in the suggestion condition. Experients of visual apparitions were found to significantly differ from nonexperients in their preference for a visual cognitive style independently of condition.

Division of Psychiatry, Boston University School of Medicine, Boston, Massachusetts 02118, USA. devin.terhune@gmail.com

Benjamin Franklin (1706-1790), who is better known in other fields, especially colonial politics and international diplomacy, was an early, major contributor to the neurosciences from the New World. Among his accomplishments are: experiments on medical electricity as a possible cure for the palsies and hysteria; the first descriptions of how electricity affecting the brain can cause a specific type of amnesia; supporting the idea that cranial shocks might provide a cure for melancholia; showing that the cures performed by the Mesmerists to remove obstructions, including nerve blockages, rest on gullibility and suggestion, and recognizing the dangers, including those to the nerves, posed by exposure to lead. Franklin?s neuroscience was firmly based on experiments, careful observations, and hard data ? and finding clinical relevance for new discoveries was always on his mind.

Department of Psychology, University of Washington, USA. sfinger@wustl.edu

In this article, the nature of hypnosis will be discussed, together with its therapeutic/facilitator role in the control of the potential problems that occur in everyday dental practice. It is the vital relationship between a patient and therapist which produces the desired results of hypnotherapy. CLINICAL RELEVANCE: A holistic approach, in patient care, emphasizes the treatment of an individual who has a dental problem.