Chin Med. 2011 Jun 9;6(1):22. Carmady B, Smith CA.
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Chin Med. 2011 Jun 9;6(1):22. Carmady B, Smith CA.
Traditional Chinese medicine (TCM) is a holistic approach to health that attempts to bring the body, mind and spirit into harmony. Entering 21st century, TCM is getting more and more popular in the whole world for improving health condition of human beings and preventing or healing diseases, especially shows great advantages in early intervention, combination therapies and personalized medicine, etc. However, like almost all other ethnopharmacology, TCM also faces severe challenges and suffers from insufficient modern research owing to lack of scientific and technologic approaches, restricts the development of TCM in the world. Fortunately, a novel analytical technique, metabolomics (or metabonomics), adopts a 'top-down' strategy to reflect the function of organisms from terminal symptoms of metabolic network and understand metabolic changes of a complete system caused by interventions in holistic context. Its property consists with the holistic thinking of TCM, may beneficially provide an opportunity to scientifically express the meaning of evidence-based Chinese medicine, such as Chinese medicine syndromes (CMS), preventive treatment, action of Chinese medicine, Chinese medical formulae (CMF) and acupuncture efficacy. This review summarizes potential applications of robust metabolomics apporoaches in the area of traditional oriental medicine, and highlights the key role of metabolomics to resolve special TCM issues.
J Pharm Biomed Anal. 2011 Jul 15;55(5):859-68. Epub 2011 Feb 26. Wang X, Sun H, Zhang A, Sun W, Wang P, Wang Z. National TCM Key Lab of Serum Pharmacochemistry, Heilongjiang University of Chinese Medicine, Heping Road 24, Harbin 150040, China.
METHODS: The 51 outpatients were treated by basic recipe for massage treatment and modified recipe according to syndromes.
RESULTS: The total Athens Insomnia Scale (AIS) score 3.2800 +/- 1.5784 after treatment is lower than 9.2400 +/- 1.4286 before treatment (P < 0.01), there is statistical difference in AIS scores before and after treatment.
CONCLUSION: TCM massage can remarkably improve sleep condition of infants with dyssomnia.
J Tradit Chin Med. 2010 Dec;30(4):299-301. Dong HY, Wang W. Acupuncture and Moxibustion College of Tianjin TCM University, Tianjin 300193, China.
He W, Xie Y, Wang Y. Zhongguo Zhong Yao Za Zhi. 2010 Jun;35(11):1498-500. Institute of Basic Research in Clinical Medicine, China Academy of Chinese Medical Sciences, Beijing 100700, China. email@example.com
Human steroid 5alpha-reductase type II (hSRD5A2) and dihydrotestosterone (DHT) play important roles in benign prostatic hyperplasia (BPH). The aim of our study was to establish a novel model to investigate the inhibitory effects of extracts and compounds of Chinese herb medicine on hSRD5A2. The gene, hSRD5A2, was artificially synthesized and cloned into pcDNA3.1(+) vector, which was transfected into CHO cells by liposome. Transfected cells were screened through G418 and MTX. The expressed protein of hSRD5A2 by cells was purified and detected by western blotting. A minim reactive system comprising hSRD5A2 and testosterone (T) as substrate together with NADPH as hydrogen donor was established for screening inhibitors of hSRD5A2. The reaction system was optimized in the concentrations of T, NADPH, and hSRD5A2 and reaction temperature, time, and activity of hSRD5A2 were determined by the production of DHT. Furthermore, we screened some extracts and compounds of Chinese herb medicine using this model. The concentrations of T, NADPH, and hSRD5A2 were 0.02 microM, 0.8 mM, and 0.05 U/microl, respectively, in the model; maximum activity of hSRD5A2 was achieved at 37 degrees C and 60 min reaction, and mangiferin had significant inhibitory effect on the activity of hSRD5A2. The model in this study is convenient and reliable for screening and evaluation of inhibitors of hSRD5A2; mangiferin may be a potential medicine for the treatment of BPH.
Wang X, Liao J, Yin D, Zhan F, Dai S, Xie G, Sang X. Yakugaku Zasshi. 2010 Sep;130(9):1207-14. Department of Pharmacy, Anhui University of Traditional Chinese Medicine.
Rheumatoid arthritis (RA) is difficult to cure. Many methods have been used for its treatment, among which traditional Chinese medicine (TCM) has been considered as an important strategy. All of the three parts of TCM: Chinese herbs, acupuncture, and massage have been reported with varying degrees of therapeutic effects on RA. Also the mechanism exploration is under process. Many effective ingredients of anti-rheumatic Chinese herbs have been found to inhibit RA development and some of the effective ingredients have been verified. Furthermore, greatly enhanced life quality of RA patients was obtained using acupuncture and massage to relieve pain, expand joint motion and modulate emotion which mainly correlated with the possible modulation of immune system, nerve system, endocrine system, etc. Thus, a systemic review on the therapeutic effect of TCM on RA is necessary. In our paper, the current status of TCM application in the clinic for the therapy of RA was summarized accompanied with the related mechanism exploration using modern test facilities.
Rheumatol Int. 2010 Apr;30(6):713-8. Epub 2010 Mar 5. Zhang P, Li J, Han Y, Yu XW, Qin L. The Translational Medicine R&D Center, Shen Zhen Institute of Advanced Technology, Chinese Academy of Science, Shen Zhen, GuangDong Province, China. firstname.lastname@example.org
Eur Arch Otorhinolaryngol. 2009 Sep;266(9):1353-9. Epub 2009 Jul 14. Yap L, Pothula VB, Warner J, Akhtar S, Yates E. Royal Albert Edward Infirmary, Wigan, UK. email@example.com
Evid Based Complement Alternat Med. 2009 Apr 1. Chen FP, Jong MS, Chen YC, Kung YY, Chen TJ, Chen FJ, Hwang SJ. Department of Family Medicine, Taipei Veterans General Hospital, No. 201, Sec. 2, Shih-Pai Road, Taipei 112, Taiwan, ROC. firstname.lastname@example.org.
Biogerontology. 2009 Apr;10(2):109-23. May BH, Yang AW, Zhang AL, Owens MD, Bennett L, Head R, Cobiac L, Li CG, Hugel H, Story DF, Xue CC. WHO Collaborating Centre for Traditional Medicine, Division of Chinese Medicine, School of Health Sciences, RMIT University, Bundoora, VIC, 3083, Australia.
Wang J, He QY, Li HX, Fang YT. Department of Cardiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China; E-mail: email@example.com. Zhong Xi Yi Jie He Xue Bao. 2008 Aug;6(8):788-92.
Ritenbaugh C, Hammerschlag R, Calabrese C, Mist S, Aickin M, Sutherland E, Leben J, Debar L, Elder C, Dworkin SF. Department of Family and Community Medicine, The University of Arizona, Tucson, AZ 85719, USA. firstname.lastname@example.org J Altern Complement Med. 2008 Jun;14(5):475-87.